Interplay between metabolic identities in the intestinal crypt supports stem cell function

Maria J. Rodríguez-Colman, Matthias Schewe, Maaike Meerlo, Edwin Stigter, Johan Gerrits, Mia Pras-Raves, Andrea Sacchetti, Marten Hornsveld, Koen C. Oost, Hugo J. Snippert, Nanda Verhoeven-Duif, Riccardo Fodde and Boudewijn M. T. Burgering ()
Additional contact information
Maria J. Rodríguez-Colman: Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht
Matthias Schewe: Erasmus MC Cancer Institute, Erasmus University Medical Center
Maaike Meerlo: Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht
Edwin Stigter: Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht
Johan Gerrits: Department of Genetics and Center for Molecular Medicine
Mia Pras-Raves: Department of Genetics and Center for Molecular Medicine
Andrea Sacchetti: Erasmus MC Cancer Institute, Erasmus University Medical Center
Marten Hornsveld: Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht
Koen C. Oost: Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht
Hugo J. Snippert: Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht
Nanda Verhoeven-Duif: Department of Genetics and Center for Molecular Medicine
Riccardo Fodde: Erasmus MC Cancer Institute, Erasmus University Medical Center
Boudewijn M. T. Burgering: Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht

Nature, 2017, vol. 543, issue 7645, 424-427

Abstract: The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt.

Date: 2017
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DOI: 10.1038/nature21673

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