Cytosolic proteostasis through importing of misfolded proteins into mitochondria

Linhao Ruan, Chuankai Zhou, Erli Jin, Andrei Kucharavy, Ying Zhang, Zhihui Wen, Laurence Florens and Rong Li ()
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Linhao Ruan: Center for Cell Dynamics, Johns Hopkins University School of Medicine
Chuankai Zhou: Stowers Institute for Medical Research
Erli Jin: Whiting School of Engineering, Johns Hopkins University
Andrei Kucharavy: Center for Cell Dynamics, Johns Hopkins University School of Medicine
Ying Zhang: Stowers Institute for Medical Research
Zhihui Wen: Stowers Institute for Medical Research
Laurence Florens: Stowers Institute for Medical Research
Rong Li: Center for Cell Dynamics, Johns Hopkins University School of Medicine

Nature, 2017, vol. 543, issue 7645, 443-446

Abstract: Proteins prone to aggregation in yeast are imported into mitochondria under stress conditions, suggesting that mitochondrial import and proteolysis may help to disaggregate proteins in the cytoplasm.

Date: 2017
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DOI: 10.1038/nature21695

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