Hypersensitive termination of the hypoxic response by a disordered protein switch

Rebecca B. Berlow, H. Jane Dyson and Peter E. Wright ()
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Rebecca B. Berlow: The Scripps Research Institute
H. Jane Dyson: The Scripps Research Institute
Peter E. Wright: The Scripps Research Institute

Nature, 2017, vol. 543, issue 7645, 447-451

Abstract: The intrinsically disordered CITED2 negative feedback regulator displaces the tightly bound hypoxia-inducible transcription factor HIF-1α from their common target TAZ1 through the formation of an intermediate ternary complex and thereby attenuates the hypoxic response.

Date: 2017
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DOI: 10.1038/nature21705

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