DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs

Masashi Yamaji, Miki Jishage, Cindy Meyer, Hemant Suryawanshi, Evan Der, Misaki Yamaji, Aitor Garzia, Pavel Morozov, Sudhir Manickavel, Hannah L. McFarland, Robert G. Roeder, Markus Hafner () and Thomas Tuschl ()
Additional contact information
Masashi Yamaji: Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
Miki Jishage: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
Cindy Meyer: Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
Hemant Suryawanshi: Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
Evan Der: Albert Einstein College of Medicine
Misaki Yamaji: Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
Aitor Garzia: Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
Pavel Morozov: Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
Sudhir Manickavel: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease
Hannah L. McFarland: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease
Robert G. Roeder: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
Markus Hafner: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease
Thomas Tuschl: Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University

Nature, 2017, vol. 543, issue 7646, 568-572

Abstract: The vertebrate-conserved and germline-specific RNA-binding protein DND1 recruits the CCR4–NOT deadenylase complex to destabilize its mRNA targets and is required for the maintenance of germline stem cells.

Date: 2017
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DOI: 10.1038/nature21690

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