Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian, Yelena Peskova, Hanane A. Koteiche, Robert K. Nakamoto, Emad Tajkhorshid and Hassane S. Mchaourab ()
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Brandy Verhalen: Vanderbilt University
Reza Dastvan: Vanderbilt University
Sundarapandian Thangapandian: Center for Biophysics and Quantitative Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign
Yelena Peskova: University of Virginia
Hanane A. Koteiche: Vanderbilt University
Robert K. Nakamoto: University of Virginia
Emad Tajkhorshid: Center for Biophysics and Quantitative Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign
Hassane S. Mchaourab: Vanderbilt University

Nature, 2017, vol. 543, issue 7647, 738-741

Abstract: Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.

Date: 2017
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DOI: 10.1038/nature21414

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