The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegué and Mark R. Looney ()
Additional contact information
Emma Lefrançais: University of California, San Francisco (UCSF)
Guadalupe Ortiz-Muñoz: University of California, San Francisco (UCSF)
Axelle Caudrillier: University of California, San Francisco (UCSF)
Beñat Mallavia: University of California, San Francisco (UCSF)
Fengchun Liu: University of California, San Francisco (UCSF)
David M. Sayah: University of California, Los Angeles (UCLA)
Emily E. Thornton: University of California, San Francisco (UCSF)
Mark B. Headley: University of California, San Francisco (UCSF)
Tovo David: Cardiovascular Research Institute, University of California, San Francisco (UCSF)
Shaun R. Coughlin: Cardiovascular Research Institute, University of California, San Francisco (UCSF)
Matthew F. Krummel: University of California, San Francisco (UCSF)
Andrew D. Leavitt: University of California, San Francisco (UCSF)
Emmanuelle Passegué: University of California, San Francisco (UCSF)
Mark R. Looney: University of California, San Francisco (UCSF)

Nature, 2017, vol. 544, issue 7648, 105-109

Abstract: Direct imaging of the lung microcirculation in mice indicates that it is a major site of mature platelet production from megakaryocytes.

Date: 2017
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DOI: 10.1038/nature21706

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