Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition

Ilya M. Flyamer, Johanna Gassler, Maxim Imakaev, Hugo B. Brandão, Sergey V. Ulianov, Nezar Abdennur, Sergey V. Razin, Leonid A. Mirny () and Kikuë Tachibana-Konwalski ()
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Ilya M. Flyamer: IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter (VBC)
Johanna Gassler: IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter (VBC)
Maxim Imakaev: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
Hugo B. Brandão: Harvard Program in Biophysics, Harvard University
Sergey V. Ulianov: Institute of Gene Biology, Russian Academy of Sciences
Nezar Abdennur: Computational and Systems Biology Program, Massachusetts Institute of Technology (MIT),
Sergey V. Razin: Institute of Gene Biology, Russian Academy of Sciences
Leonid A. Mirny: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
Kikuë Tachibana-Konwalski: IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter (VBC)

Nature, 2017, vol. 544, issue 7648, 110-114

Abstract: Using a single-nucleus Hi-C protocol, the authors find that spatial organization of chromatin during oocyte-to-zygote transition differs between paternal and maternal nuclei within a single-cell zygote.

Date: 2017
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DOI: 10.1038/nature21711

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