Structural insights into adiponectin receptors suggest ceramidase activity

Ieva Vasiliauskaité-Brooks, Remy Sounier, Pascal Rochaix, Gaëtan Bellot, Mathieu Fortier, François Hoh, Luigi De Colibus, Chérine Bechara, Essa M. Saied, Christoph Arenz, Cédric Leyrat () and Sébastien Granier ()
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Ieva Vasiliauskaité-Brooks: Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier
Remy Sounier: Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier
Pascal Rochaix: Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier
Gaëtan Bellot: Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier
Mathieu Fortier: Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier
François Hoh: Centre de Biochimie Structurale, CNRS UMR 5048-INSERM 1054 University of Montpellier
Luigi De Colibus: University of Oxford
Chérine Bechara: Dynamique des Interactions Membranaires Normales et Pathologiques, CNRS UMR5235, University of Montpellier
Essa M. Saied: Institute for chemistry, Humboldt-Universität zu Berlin
Christoph Arenz: Institute for chemistry, Humboldt-Universität zu Berlin
Cédric Leyrat: Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier
Sébastien Granier: Institut de Génomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier

Nature, 2017, vol. 544, issue 7648, 120-123

Abstract: Structures of the adiponectin receptors ADIPOR1 and ADIPOR2 combined with molecular dynamics simulations and enzymatic assays suggest that both receptors have intrinsic ceramidase activity.

Date: 2017
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DOI: 10.1038/nature21714

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