Topological defects in epithelia govern cell death and extrusion

Thuan Beng Saw, Amin Doostmohammadi, Vincent Nier, Leyla Kocgozlu, Sumesh Thampi, Yusuke Toyama, Philippe Marcq, Chwee Teck Lim (), Julia M. Yeomans () and Benoit Ladoux ()
Additional contact information
Thuan Beng Saw: Mechanobiology Institute
Amin Doostmohammadi: The Rudolf Peierls Centre for Theoretical Physics, University of Oxford
Vincent Nier: Laboratoire Physico-Chimie Curie, Sorbonne Universités, UPMC Université Paris 6, Institut Curie, CNRS, UMR 168
Leyla Kocgozlu: Mechanobiology Institute
Sumesh Thampi: The Rudolf Peierls Centre for Theoretical Physics, University of Oxford
Yusuke Toyama: Mechanobiology Institute
Philippe Marcq: Laboratoire Physico-Chimie Curie, Sorbonne Universités, UPMC Université Paris 6, Institut Curie, CNRS, UMR 168
Chwee Teck Lim: Mechanobiology Institute
Julia M. Yeomans: The Rudolf Peierls Centre for Theoretical Physics, University of Oxford
Benoit Ladoux: Mechanobiology Institute

Nature, 2017, vol. 544, issue 7649, 212-216

Abstract: By modelling epithelial cells as active nematic liquid crystals, stresses induced at the sites of topological defects are found to be the primary drivers of extrusion and cell death.

Date: 2017
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DOI: 10.1038/nature21718

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