Rad51-mediated double-strand break repair and mismatch correction of divergent substrates

Ranjith Anand, Annette Beach, Kevin Li and James Haber ()
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Ranjith Anand: Brandeis University
Annette Beach: Brandeis University
Kevin Li: Brandeis University
James Haber: Brandeis University

Nature, 2017, vol. 544, issue 7650, 377-380

Abstract: DNA repair by break-induced replication begins with the Rad51-mediated invasion of single-stranded DNA into a double-stranded donor template; this study shows that successful recombination between highly mismatched substrates can occur when only five consecutive bases can be paired and that mismatch correction is most efficient near the invading end of the recipient strand.

Date: 2017
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DOI: 10.1038/nature22046

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