Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Oliver D. K. Maddocks (), Dimitris Athineos, Eric C. Cheung, Pearl Lee, Tong Zhang, Niels J. F. van den Broek, Gillian M. Mackay, Christiaan F. Labuschagne, David Gay, Flore Kruiswijk, Julianna Blagih, David F. Vincent, Kirsteen J. Campbell, Fatih Ceteci, Owen J. Sansom, Karen Blyth and Karen H. Vousden ()
Additional contact information
Oliver D. K. Maddocks: Cancer Research UK Beatson Institute
Dimitris Athineos: Cancer Research UK Beatson Institute
Eric C. Cheung: Cancer Research UK Beatson Institute
Pearl Lee: Cancer Research UK Beatson Institute
Tong Zhang: University of Glasgow Institute of Cancer Sciences
Niels J. F. van den Broek: Cancer Research UK Beatson Institute
Gillian M. Mackay: Cancer Research UK Beatson Institute
Christiaan F. Labuschagne: Cancer Research UK Beatson Institute
David Gay: Cancer Research UK Beatson Institute
Flore Kruiswijk: Cancer Research UK Beatson Institute
Julianna Blagih: Cancer Research UK Beatson Institute
David F. Vincent: Cancer Research UK Beatson Institute
Kirsteen J. Campbell: Cancer Research UK Beatson Institute
Fatih Ceteci: Cancer Research UK Beatson Institute
Owen J. Sansom: Cancer Research UK Beatson Institute
Karen Blyth: Cancer Research UK Beatson Institute
Karen H. Vousden: Cancer Research UK Beatson Institute

Nature, 2017, vol. 544, issue 7650, 372-376

Abstract: Dependence on exogenous serine means that tumour growth is restricted in mice on a low-serine diet; this effect on tumour growth can be amplified by antagonizing the antioxidant response.

Date: 2017
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DOI: 10.1038/nature22056

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