Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

Thomas Kammertoens, Christian Friese, Ainhoa Arina, Christian Idel, Dana Briesemeister, Michael Rothe, Andranik Ivanov, Anna Szymborska, Giannino Patone, Severine Kunz, Daniel Sommermeyer, Boris Engels, Matthias Leisegang, Ana Textor, Hans Joerg Fehling, Marcus Fruttiger, Michael Lohoff, Andreas Herrmann, Hua Yu, Ralph Weichselbaum, Wolfgang Uckert, Norbert Hübner, Holger Gerhardt, Dieter Beule, Hans Schreiber and Thomas Blankenstein ()
Additional contact information
Thomas Kammertoens: Institute of Immunology, Charité Campus Buch
Christian Friese: Institute of Immunology, Charité Campus Buch
Ainhoa Arina: Ludwig Center for Metastasis Research, The University of Chicago
Christian Idel: The University of Chicago
Dana Briesemeister: Institute of Immunology, Charité Campus Buch
Michael Rothe: Institute of Immunology, Charité Campus Buch
Andranik Ivanov: Berlin Institute of Health
Anna Szymborska: Max Delbrück Center for Molecular Medicine
Giannino Patone: Max Delbrück Center for Molecular Medicine
Severine Kunz: Max Delbrück Center for Molecular Medicine
Daniel Sommermeyer: Max Delbrück Center for Molecular Medicine
Boris Engels: Max Delbrück Center for Molecular Medicine
Matthias Leisegang: Institute of Immunology, Charité Campus Buch
Ana Textor: Institute of Immunology, Charité Campus Buch
Hans Joerg Fehling: Institute of Immunology, University Clinics Ulm
Marcus Fruttiger: Institute of Ophthalmology, University College London
Michael Lohoff: Institute for Medical Microbiology, University of Marburg
Andreas Herrmann: Beckman Research Institute at the Comprehensive Cancer Center City of Hope, Los Angeles
Hua Yu: Beckman Research Institute at the Comprehensive Cancer Center City of Hope, Los Angeles
Ralph Weichselbaum: Ludwig Center for Metastasis Research, The University of Chicago
Wolfgang Uckert: Max Delbrück Center for Molecular Medicine
Norbert Hübner: Max Delbrück Center for Molecular Medicine
Holger Gerhardt: Max Delbrück Center for Molecular Medicine
Dieter Beule: Max Delbrück Center for Molecular Medicine
Hans Schreiber: Institute of Immunology, Charité Campus Buch
Thomas Blankenstein: Institute of Immunology, Charité Campus Buch

Nature, 2017, vol. 545, issue 7652, 98-102

Abstract: Interferon-γ acts on tumour endothelial cells to drive vascular regression, inducing ischaemia that leads to tumour collapse.

Date: 2017
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DOI: 10.1038/nature22311

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