Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Claudia Y. Janda, Luke T. Dang, Changjiang You, Junlei Chang, Wim de Lau, Zhendong A. Zhong, Kelley S. Yan, Owen Marecic, Dirk Siepe, Xingnan Li, James D. Moody, Bart O. Williams, Hans Clevers, Jacob Piehler, David Baker, Calvin J. Kuo and K. Christopher Garcia ()
Additional contact information
Claudia Y. Janda: Howard Hughes Medical Institute, Stanford University School of Medicine
Luke T. Dang: Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington
Changjiang You: University of Osnabrück
Junlei Chang: Stanford University School of Medicine
Wim de Lau: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht
Zhendong A. Zhong: Program for Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Research Institute
Kelley S. Yan: Stanford University School of Medicine
Owen Marecic: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Dirk Siepe: Howard Hughes Medical Institute, Stanford University School of Medicine
Xingnan Li: Stanford University School of Medicine
James D. Moody: Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington
Bart O. Williams: Program for Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Research Institute
Hans Clevers: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht
Jacob Piehler: University of Osnabrück
David Baker: Howard Hughes Medical Institute, and the Institute for Protein Design, University of Washington
Calvin J. Kuo: Stanford University School of Medicine
K. Christopher Garcia: Howard Hughes Medical Institute, Stanford University School of Medicine

Nature, 2017, vol. 545, issue 7653, 234-237

Abstract: The authors describe water-soluble surrogate Wnt agonists, with specificity towards some frizzled (FZD) receptors, which can maintain human intestinal organoid cultures and have effects on the mouse liver in vivo.

Date: 2017
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DOI: 10.1038/nature22306

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