Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

Kelley S. Yan, Claudia Y. Janda, Junlei Chang, Grace X. Y. Zheng, Kathryn A. Larkin, Vincent C. Luca, Luis A. Chia, Amanda T. Mah, Arnold Han, Jessica M. Terry, Akifumi Ootani, Kelly Roelf, Mark Lee, Jenny Yuan, Xiao Li, Christopher R. Bolen, Julie Wilhelmy, Paige S. Davies, Hiroo Ueno, Richard J. von Furstenberg, Phillip Belgrader, Solongo B. Ziraldo, Heather Ordonez, Susan J. Henning, Melissa H. Wong, Michael P. Snyder, Irving L. Weissman, Aaron J. Hsueh, Tarjei S. Mikkelsen, K. Christopher Garcia and Calvin J. Kuo ()
Additional contact information
Kelley S. Yan: Stanford University School of Medicine
Claudia Y. Janda: Howard Hughes Medical Institute, Stanford University School of Medicine
Junlei Chang: Stanford University School of Medicine
Grace X. Y. Zheng: 10x Genomics, Inc.
Kathryn A. Larkin: Stanford University School of Medicine
Vincent C. Luca: Howard Hughes Medical Institute, Stanford University School of Medicine
Luis A. Chia: Stanford University School of Medicine
Amanda T. Mah: Stanford University School of Medicine
Arnold Han: Stanford University School of Medicine
Jessica M. Terry: 10x Genomics, Inc.
Akifumi Ootani: Stanford University School of Medicine
Kelly Roelf: Stanford University School of Medicine
Mark Lee: Stanford University School of Medicine
Jenny Yuan: Stanford University School of Medicine
Xiao Li: Stanford University School of Medicine
Christopher R. Bolen: Stanford University School of Medicine
Julie Wilhelmy: Stanford University School of Medicine
Paige S. Davies: Oregon Health & Science University, Developmental and Cancer Biology
Hiroo Ueno: Institute for Stem Cell Biology, Stanford University School of Medicine
Richard J. von Furstenberg: University of North Carolina at Chapel Hill
Phillip Belgrader: 10x Genomics, Inc.
Solongo B. Ziraldo: 10x Genomics, Inc.
Heather Ordonez: 10x Genomics, Inc.
Susan J. Henning: University of North Carolina at Chapel Hill
Melissa H. Wong: Oregon Health & Science University, Developmental and Cancer Biology
Michael P. Snyder: Stanford University School of Medicine
Irving L. Weissman: Institute for Stem Cell Biology, Stanford University School of Medicine
Aaron J. Hsueh: Stanford University School of Medicine
Tarjei S. Mikkelsen: 10x Genomics, Inc.
K. Christopher Garcia: Howard Hughes Medical Institute, Stanford University School of Medicine
Calvin J. Kuo: Stanford University School of Medicine

Nature, 2017, vol. 545, issue 7653, 238-242

Abstract: R-spondin and Wnt ligand families act non-redundantly and cooperatively within the same molecular pathway in the intestinal stem-cell niche to maintain stem-cell competency and drive stem-cell expansion.

Date: 2017
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DOI: 10.1038/nature22313

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