Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Joshua D. Ooi, Jan Petersen, Yu H. Tan, Megan Huynh, Zoe J. Willett, Sri H. Ramarathinam, Peter J. Eggenhuizen, Khai L. Loh, Katherine A. Watson, Poh Y. Gan, Maliha A. Alikhan, Nadine L. Dudek, Andreas Handel, Billy G. Hudson, Lars Fugger, David A. Power, Stephen G. Holt, P. Toby Coates, Jon W. Gregersen, Anthony W. Purcell, Stephen R. Holdsworth, Nicole L. La Gruta, Hugh H. Reid (), Jamie Rossjohn () and A. Richard Kitching ()
Additional contact information
Joshua D. Ooi: Centre for Inflammatory Diseases, Monash Medical Centre
Jan Petersen: Biomedicine Discovery Institute, Monash University
Yu H. Tan: Biomedicine Discovery Institute, Monash University
Megan Huynh: Centre for Inflammatory Diseases, Monash Medical Centre
Zoe J. Willett: Centre for Inflammatory Diseases, Monash Medical Centre
Sri H. Ramarathinam: Biomedicine Discovery Institute, Monash University
Peter J. Eggenhuizen: Centre for Inflammatory Diseases, Monash Medical Centre
Khai L. Loh: Biomedicine Discovery Institute, Monash University
Katherine A. Watson: The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Poh Y. Gan: Centre for Inflammatory Diseases, Monash Medical Centre
Maliha A. Alikhan: Centre for Inflammatory Diseases, Monash Medical Centre
Nadine L. Dudek: Biomedicine Discovery Institute, Monash University
Andreas Handel: College of Public Health, University of Georgia
Billy G. Hudson: Vanderbilt University Medical Center
Lars Fugger: Oxford Centre for Neuroinflammation, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
David A. Power: Austin Health
Stephen G. Holt: University of Melbourne
P. Toby Coates: Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital
Jon W. Gregersen: Viborg Regional Hospital
Anthony W. Purcell: Biomedicine Discovery Institute, Monash University
Stephen R. Holdsworth: Centre for Inflammatory Diseases, Monash Medical Centre
Nicole L. La Gruta: Biomedicine Discovery Institute, Monash University
Hugh H. Reid: Biomedicine Discovery Institute, Monash University
Jamie Rossjohn: Biomedicine Discovery Institute, Monash University
A. Richard Kitching: Centre for Inflammatory Diseases, Monash Medical Centre

Nature, 2017, vol. 545, issue 7653, 243-247

Abstract: The molecular mechanism of Goodpasture disease is modelled to mechanistically determine how a human leukocyte antigen (HLA) allele can exert its dominant protective effect in autoimmune disease.

Date: 2017
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DOI: 10.1038/nature22329

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