Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Jing Shan Lim, Alvaro Ibaseta, Marcus M. Fischer, Belinda Cancilla, Gilbert O’Young, Sandra Cristea, Vincent C. Luca, Dian Yang, Nadine S. Jahchan, Cécile Hamard, Martine Antoine, Marie Wislez, Christina Kong, Jennifer Cain, Yu-Wang Liu, Ann M. Kapoun, K. Christopher Garcia, Timothy Hoey, Christopher L. Murriel and Julien Sage ()
Additional contact information
Jing Shan Lim: Stanford University School of Medicine
Alvaro Ibaseta: Stanford University School of Medicine
Marcus M. Fischer: OncoMed Pharmaceuticals, Inc.
Belinda Cancilla: OncoMed Pharmaceuticals, Inc.
Gilbert O’Young: OncoMed Pharmaceuticals, Inc.
Sandra Cristea: Stanford University School of Medicine
Vincent C. Luca: Stanford University School of Medicine
Dian Yang: Stanford University School of Medicine
Nadine S. Jahchan: Stanford University School of Medicine
Cécile Hamard: Sorbonne Universités, UPMC Univ Paris 06, GRC n°04
Martine Antoine: Sorbonne Universités, UPMC Univ Paris 06, GRC n°04
Marie Wislez: Sorbonne Universités, UPMC Univ Paris 06, GRC n°04
Christina Kong: Stanford University School of Medicine
Jennifer Cain: OncoMed Pharmaceuticals, Inc.
Yu-Wang Liu: OncoMed Pharmaceuticals, Inc.
Ann M. Kapoun: OncoMed Pharmaceuticals, Inc.
K. Christopher Garcia: Stanford University School of Medicine
Timothy Hoey: OncoMed Pharmaceuticals, Inc.
Christopher L. Murriel: OncoMed Pharmaceuticals, Inc.
Julien Sage: Stanford University School of Medicine

Nature, 2017, vol. 545, issue 7654, 360-364

Abstract: In a mouse model of small-cell lung cancer and in human tumours, activation of the Notch pathway can lead to a cell fate switch of neuroendocrine cells to less proliferative non-neuroendocrine cells, generating intratumoural heterogeneity.

Date: 2017
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DOI: 10.1038/nature22323

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