Floor-plate-derived netrin-1 is dispensable for commissural axon guidance

Chloé Dominici, Juan Antonio Moreno-Bravo, Sergi Roig Puiggros, Quentin Rappeneau, Nicolas Rama, Pauline Vieugue, Agns Bernet, Patrick Mehlen () and Alain Chédotal ()
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Chloé Dominici: Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision
Juan Antonio Moreno-Bravo: Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision
Sergi Roig Puiggros: Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision
Quentin Rappeneau: Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision
Nicolas Rama: Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Pauline Vieugue: Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Agns Bernet: Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Patrick Mehlen: Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon
Alain Chédotal: Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision

Nature, 2017, vol. 545, issue 7654, 350-354

Abstract: Preventing netrin secretion from floor-plate cells at the midline does not disrupt axonal guidance; commissural axons develop normally and the data suggest that netrin may influence axons locally by promoting growth cone adhesion.

Date: 2017
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DOI: 10.1038/nature22331

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