A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

Tuomas Tammela, Francisco J. Sanchez-Rivera, Naniye Malli Cetinbas, Katherine Wu, Nikhil S. Joshi, Katja Helenius, Yoona Park, Roxana Azimi, Natanya R. Kerper, R. Alexander Wesselhoeft, Xin Gu, Leah Schmidt, Milton Cornwall-Brady, Ömer H. Yilmaz, Wen Xue, Pekka Katajisto, Arjun Bhutkar and Tyler Jacks ()
Additional contact information
Tuomas Tammela: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Francisco J. Sanchez-Rivera: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Naniye Malli Cetinbas: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Katherine Wu: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Nikhil S. Joshi: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Katja Helenius: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Yoona Park: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Roxana Azimi: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Natanya R. Kerper: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
R. Alexander Wesselhoeft: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Xin Gu: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Leah Schmidt: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Milton Cornwall-Brady: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Ömer H. Yilmaz: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Wen Xue: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Pekka Katajisto: Institute of Biotechnology, University of Helsinki
Arjun Bhutkar: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Tyler Jacks: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology

Nature, 2017, vol. 545, issue 7654, 355-359

Abstract: A subset of Kras and p53 mutant cancer cells acts as a Wnt-producing niche for another cancer cell subset, and porcupine inhibition disrupts Wnt secretion in this niche, thereby suppressing proliferative potential and leading to therapeutic benefit.

Date: 2017
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DOI: 10.1038/nature22334

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