TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

Bin Wang, Zuliang Jie, Donghyun Joo, Alban Ordureau, Pengda Liu, Wenjian Gan, Jianping Guo, Jinfang Zhang, Brian J. North, Xiangpeng Dai, Xuhong Cheng, Xiuwu Bian, Lingqiang Zhang, J. Wade Harper, Shao-Cong Sun () and Wenyi Wei ()
Additional contact information
Bin Wang: Institute of Surgery Research, Daping Hospital, Third Military Medical University
Zuliang Jie: The University of Texas MD Anderson Cancer Center
Donghyun Joo: The University of Texas MD Anderson Cancer Center
Alban Ordureau: Harvard Medical School
Pengda Liu: Beth Israel Deaconess Medical Center, Harvard Medical School
Wenjian Gan: Beth Israel Deaconess Medical Center, Harvard Medical School
Jianping Guo: Beth Israel Deaconess Medical Center, Harvard Medical School
Jinfang Zhang: Beth Israel Deaconess Medical Center, Harvard Medical School
Brian J. North: Beth Israel Deaconess Medical Center, Harvard Medical School
Xiangpeng Dai: Beth Israel Deaconess Medical Center, Harvard Medical School
Xuhong Cheng: The University of Texas MD Anderson Cancer Center
Xiuwu Bian: Institute of Pathology and Southwest Cancer Center and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Southwest Hospital, Third Military Medical University
Lingqiang Zhang: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine
J. Wade Harper: Harvard Medical School
Shao-Cong Sun: The University of Texas MD Anderson Cancer Center
Wenyi Wei: Beth Israel Deaconess Medical Center, Harvard Medical School

Nature, 2017, vol. 545, issue 7654, 365-369

Abstract: Ubiquitination of the GβL subunit, a component of both mTORC1 and mTORC2, acts as a regulatory switching mechanism to balance levels of mTORC1 and mTORC2; the failure of this mechanism in some cancers leads to elevated mTORC2 formation and tumorigenesis.

Date: 2017
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DOI: 10.1038/nature22344

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