Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

Yang Liu, Jianying Liu, Senyan Du, Chao Shan, Kaixiao Nie, Rudian Zhang, Xiao-Feng Li, Renli Zhang, Tao Wang, Cheng-Feng Qin, Penghua Wang, Pei-Yong Shi () and Gong Cheng ()
Additional contact information
Yang Liu: Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
Jianying Liu: Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
Senyan Du: Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
Chao Shan: and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch
Kaixiao Nie: Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
Rudian Zhang: Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
Xiao-Feng Li: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Renli Zhang: SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention
Tao Wang: SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention
Cheng-Feng Qin: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Penghua Wang: School of Medicine, New York Medical College
Pei-Yong Shi: and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch
Gong Cheng: Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University

Nature, 2017, vol. 545, issue 7655, 482-486

Abstract: A mutation that increases the secretion of Zika virus non-structural protein 1 (NS1) in infected hosts enhances the ability of the virus to infect its mosquito vector Aedes aegypti and might have contributed to the recent Zika epidemic.

Date: 2017
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DOI: 10.1038/nature22365

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