Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin (), Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K. G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi () and J. Wade Harper ()
Additional contact information
Edward L. Huttlin: Harvard Medical School
Raphael J. Bruckner: Harvard Medical School
Joao A. Paulo: Harvard Medical School
Joe R. Cannon: Harvard Medical School
Lily Ting: Harvard Medical School
Kurt Baltier: Harvard Medical School
Greg Colby: Harvard Medical School
Fana Gebreab: Harvard Medical School
Melanie P. Gygi: Harvard Medical School
Hannah Parzen: Harvard Medical School
John Szpyt: Harvard Medical School
Stanley Tam: Harvard Medical School
Gabriela Zarraga: Harvard Medical School
Laura Pontano-Vaites: Harvard Medical School
Sharan Swarup: Harvard Medical School
Anne E. White: Harvard Medical School
Devin K. Schweppe: Harvard Medical School
Ramin Rad: Harvard Medical School
Brian K. Erickson: Harvard Medical School
Robert A. Obar: Harvard Medical School
K. G. Guruharsha: Biogen Inc.
Kejie Li: Biogen Inc.
Spyros Artavanis-Tsakonas: Harvard Medical School
Steven P. Gygi: Harvard Medical School
J. Wade Harper: Harvard Medical School

Nature, 2017, vol. 545, issue 7655, 505-509

Abstract: Affinity purification–mass spectrometry elucidates protein interaction networks and co-complexes to build, to our knowledge, the largest experimentally derived human protein interaction network so far, termed BioPlex 2.0.

Date: 2017
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DOI: 10.1038/nature22366

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