PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Sydney R. Gordon, Roy L. Maute, Ben W. Dulken, Gregor Hutter, Benson M. George, Melissa N. McCracken, Rohit Gupta, Jonathan M. Tsai, Rahul Sinha, Daniel Corey, Aaron M. Ring, Andrew J. Connolly and Irving L. Weissman ()
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Sydney R. Gordon: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Roy L. Maute: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Ben W. Dulken: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Gregor Hutter: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Benson M. George: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Melissa N. McCracken: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Rohit Gupta: Human Immune Monitoring Center Biobank, Stanford University School of Medicine
Jonathan M. Tsai: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Rahul Sinha: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Daniel Corey: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Aaron M. Ring: Yale University School of Medicine
Andrew J. Connolly: Stanford University Medical Center
Irving L. Weissman: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine

Nature, 2017, vol. 545, issue 7655, 495-499

Abstract: Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice.

Date: 2017
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DOI: 10.1038/nature22396

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