Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

Gaojie Song, Dehua Yang, Yuxia Wang, Chris de Graaf, Qingtong Zhou, Shanshan Jiang, Kaiwen Liu, Xiaoqing Cai, Antao Dai, Guangyao Lin, Dongsheng Liu, Fan Wu, Yiran Wu, Suwen Zhao, Li Ye, Gye Won Han, Jesper Lau, Beili Wu, Michael A. Hanson, Zhi-Jie Liu (), Ming-Wei Wang () and Raymond C. Stevens ()
Additional contact information
Gaojie Song: iHuman Institute, ShanghaiTech University
Dehua Yang: The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yuxia Wang: iHuman Institute, ShanghaiTech University
Chris de Graaf: Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam
Qingtong Zhou: iHuman Institute, ShanghaiTech University
Shanshan Jiang: School of Pharmacy, Fudan University
Kaiwen Liu: iHuman Institute, ShanghaiTech University
Xiaoqing Cai: The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Antao Dai: The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Guangyao Lin: School of Life Science and Technology, ShanghaiTech University
Dongsheng Liu: iHuman Institute, ShanghaiTech University
Fan Wu: iHuman Institute, ShanghaiTech University
Yiran Wu: iHuman Institute, ShanghaiTech University
Suwen Zhao: iHuman Institute, ShanghaiTech University
Li Ye: School of Pharmacy, Fudan University
Gye Won Han: Bridge Institute, University of Southern California
Jesper Lau: Novo Nordisk
Beili Wu: School of Life Science and Technology, ShanghaiTech University
Michael A. Hanson: GPCR Consortium, San Marcos
Zhi-Jie Liu: iHuman Institute, ShanghaiTech University
Ming-Wei Wang: The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Raymond C. Stevens: iHuman Institute, ShanghaiTech University

Nature, 2017, vol. 546, issue 7657, 312-315

Abstract: Crystal structures of the human GLP-1 receptor in complex with two negative allosteric modulators reveal a common binding pocket, and, together with mutagenesis and modelling studies, further our understanding of the receptor activation mechanism.Author: Please check the wording of the following statement, which will appear online only.

Date: 2017
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Citations: View citations in EconPapers (5)

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DOI: 10.1038/nature22378

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