Stability and function of regulatory T cells expressing the transcription factor T-bet

Andrew G. Levine, Alejandra Mendoza, Saskia Hemmers, Bruno Moltedo, Rachel E. Niec, Michail Schizas, Beatrice E. Hoyos, Ekaterina V. Putintseva, Ashutosh Chaudhry, Stanislav Dikiy, Sho Fujisawa, Dmitriy M. Chudakov, Piper M. Treuting and Alexander Y. Rudensky ()
Additional contact information
Andrew G. Levine: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Alejandra Mendoza: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Saskia Hemmers: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Bruno Moltedo: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Rachel E. Niec: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Michail Schizas: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Beatrice E. Hoyos: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Ekaterina V. Putintseva: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Ashutosh Chaudhry: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Stanislav Dikiy: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center
Sho Fujisawa: Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center
Dmitriy M. Chudakov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Piper M. Treuting: University of Washington School of Medicine
Alexander Y. Rudensky: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center

Nature, 2017, vol. 546, issue 7658, 421-425

Abstract: Regulatory T cells expressing the transcription factor T-bet selectively suppress TH1 and CD8 T cells, but not TH2 or TH17 activation and associated autoimmunity.

Date: 2017
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DOI: 10.1038/nature22360

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