Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein

Dong De, Minghui Guo, Sihan Wang, Yuwei Zhu, Shuo Wang, Zhi Xiong, Jianzheng Yang, Zengliang Xu and Zhiwei Huang ()
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Dong De: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Minghui Guo: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Sihan Wang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Yuwei Zhu: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Shuo Wang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Zhi Xiong: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Jianzheng Yang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Zengliang Xu: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Zhiwei Huang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology

Nature, 2017, vol. 546, issue 7658, 436-439

Abstract: The structure of the anti-CRISPR protein AcrIIA4, in complex with a single-guide RNA and Cas9, reveals that the protein inhibits DNA binding and blocks the Cas9 endonuclease active site.

Date: 2017
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DOI: 10.1038/nature22377

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