Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

Stefano Stella (), Pablo Alcón and Guillermo Montoya ()
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Stefano Stella: Protein Structure & Function Programme, Macromolecular Crystallography Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Pablo Alcón: Protein Structure & Function Programme, Macromolecular Crystallography Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Guillermo Montoya: Protein Structure & Function Programme, Macromolecular Crystallography Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen

Nature, 2017, vol. 546, issue 7659, 559-563

Abstract: The structure of Cpf1, a CRISPR–Cas/RNA-guided nuclease, is presented with a three-stranded RNA–DNA loop after cleavage, providing insight into its working mechanism.

Date: 2017
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DOI: 10.1038/nature22398

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