BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

Angela Bononi, Carlotta Giorgi, Simone Patergnani, David Larson, Kaitlyn Verbruggen, Mika Tanji, Laura Pellegrini, Valentina Signorato, Federica Olivetto, Sandra Pastorino, Masaki Nasu, Andrea Napolitano, Giovanni Gaudino, Paul Morris, Greg Sakamoto, Laura K. Ferris, Alberto Danese, Andrea Raimondi, Carlo Tacchetti, Shafi Kuchay, Harvey I. Pass, El Bachir Affar, Haining Yang (), Paolo Pinton () and Michele Carbone ()
Additional contact information
Angela Bononi: University of Hawaii Cancer Center, University of Hawaii
Carlotta Giorgi: Surgery and Experimental Medicine, University of Ferrara
Simone Patergnani: Surgery and Experimental Medicine, University of Ferrara
David Larson: University of Hawaii Cancer Center, University of Hawaii
Kaitlyn Verbruggen: University of Hawaii Cancer Center, University of Hawaii
Mika Tanji: University of Hawaii Cancer Center, University of Hawaii
Laura Pellegrini: University of Hawaii Cancer Center, University of Hawaii
Valentina Signorato: University of Hawaii Cancer Center, University of Hawaii
Federica Olivetto: University of Hawaii Cancer Center, University of Hawaii
Sandra Pastorino: University of Hawaii Cancer Center, University of Hawaii
Masaki Nasu: University of Hawaii Cancer Center, University of Hawaii
Andrea Napolitano: University of Hawaii Cancer Center, University of Hawaii
Giovanni Gaudino: University of Hawaii Cancer Center, University of Hawaii
Paul Morris: University of Hawaii Cancer Center, University of Hawaii
Greg Sakamoto: University of Hawaii Cancer Center, University of Hawaii
Laura K. Ferris: University of Pittsburgh Medical Center
Alberto Danese: Surgery and Experimental Medicine, University of Ferrara
Andrea Raimondi: Experimental Imaging Center, San Raffaele Scientific Institute Milano
Carlo Tacchetti: Experimental Imaging Center, San Raffaele Scientific Institute Milano
Shafi Kuchay: Cancer Center, New York University
Harvey I. Pass: Cancer Center, New York University
El Bachir Affar: Maisonneuve-Rosemont Hospital Research Center, University of Montréal
Haining Yang: University of Hawaii Cancer Center, University of Hawaii
Paolo Pinton: Surgery and Experimental Medicine, University of Ferrara
Michele Carbone: University of Hawaii Cancer Center, University of Hawaii

Nature, 2017, vol. 546, issue 7659, 549-553

Abstract: BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.

Date: 2017
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DOI: 10.1038/nature22798

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