Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

Matthew J. Emmett, Hee-Woong Lim, Jennifer Jager, Hannah J. Richter, Marine Adlanmerini, Lindsey C. Peed, Erika R. Briggs, David J. Steger, Tao Ma, Carrie A. Sims, Joseph A. Baur, Liming Pei, Kyoung-Jae Won, Patrick Seale, Zachary Gerhart-Hines and Mitchell A. Lazar ()
Additional contact information
Matthew J. Emmett: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Hee-Woong Lim: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Jennifer Jager: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Hannah J. Richter: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Marine Adlanmerini: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Lindsey C. Peed: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Erika R. Briggs: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
David J. Steger: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Tao Ma: Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Carrie A. Sims: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Joseph A. Baur: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Liming Pei: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Kyoung-Jae Won: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Patrick Seale: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Zachary Gerhart-Hines: Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Mitchell A. Lazar: Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania

Nature, 2017, vol. 546, issue 7659, 544-548

Abstract: Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.

Date: 2017
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DOI: 10.1038/nature22819

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