PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi, Julia Pagan, Sonia Missiroli, Anita Saraf, Laurence Florens, Michael P. Washburn, Ana Collazo-Lorduy, Mireia Castillo-Martin, Carlos Cordon-Cardo, Said M. Sebti, Paolo Pinton () and Michele Pagano ()
Additional contact information
Shafi Kuchay: New York University School of Medicine
Carlotta Giorgi: New York University School of Medicine
Daniele Simoneschi: New York University School of Medicine
Julia Pagan: New York University School of Medicine
Sonia Missiroli: Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara
Anita Saraf: The Stowers Institute for Medical Research
Laurence Florens: The Stowers Institute for Medical Research
Michael P. Washburn: The Stowers Institute for Medical Research
Ana Collazo-Lorduy: Department of Pathology at Icahn School of Medicine at Mount Sinai
Mireia Castillo-Martin: Department of Pathology at Icahn School of Medicine at Mount Sinai
Carlos Cordon-Cardo: Department of Pathology at Icahn School of Medicine at Mount Sinai
Said M. Sebti: Moffitt Cancer Center, University of South Florida
Paolo Pinton: Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara
Michele Pagano: New York University School of Medicine

Nature, 2017, vol. 546, issue 7659, 554-558

Abstract: PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.

Date: 2017
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DOI: 10.1038/nature22965

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