Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Caitlin N. Spaulding, Roger D. Klein, Ségolène Ruer, Andrew L. Kau, Henry L. Schreiber, Zachary T. Cusumano, Karen W. Dodson, Jerome S. Pinkner, Daved H. Fremont, James W. Janetka, Han Remaut, Jeffrey I. Gordon and Scott J. Hultgren ()
Additional contact information
Caitlin N. Spaulding: Washington University in St Louis
Roger D. Klein: Washington University in St Louis
Ségolène Ruer: Structural and Molecular Microbiology, VIB Center for Structural Biology
Andrew L. Kau: Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis
Henry L. Schreiber: Washington University in St Louis
Zachary T. Cusumano: Washington University in St Louis
Karen W. Dodson: Washington University in St Louis
Jerome S. Pinkner: Washington University in St Louis
Daved H. Fremont: Washington University in St Louis
James W. Janetka: Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis
Han Remaut: Structural and Molecular Microbiology, VIB Center for Structural Biology
Jeffrey I. Gordon: Center for Genome Sciences and Systems Biology, Washington University in St Louis
Scott J. Hultgren: Washington University in St Louis

Nature, 2017, vol. 546, issue 7659, 528-532

Abstract: Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.

Date: 2017
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DOI: 10.1038/nature22972

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