Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

Naomi McGovern, Amanda Shin, Gillian Low, Donovan Low, Kaibo Duan, Leong Jing Yao, Rasha Msallam, Ivy Low, Nurhidaya Binte Shadan, Hermi R Sumatoh, Erin Soon, Josephine Lum, Esther Mok, Sandra Hubert, Peter See, Edwin Huang Kunxiang, Yie Hou Lee, Baptiste Janela, Mahesh Choolani, Citra Nurfarah Zaini Mattar, Yiping Fan, Tony Kiat Hon Lim, Dedrick Kok Hong Chan, Ker-Kan Tan, John Kit Chung Tam, Christopher Schuster, Adelheid Elbe-Bürger, Xiao-nong Wang, Venetia Bigley, Matthew Collin, Muzlifah Haniffa, Andreas Schlitzer, Michael Poidinger, Salvatore Albani, Anis Larbi, Evan W Newell, Jerry Kok Yen Chan () and Florent Ginhoux ()
Additional contact information
Naomi McGovern: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Amanda Shin: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Gillian Low: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Donovan Low: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Kaibo Duan: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Leong Jing Yao: Singhealth Translational Immunology and Inflammation Centre (STIIC), 20 College Road, the Academia, Level 8 Discovery Tower
Rasha Msallam: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Ivy Low: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Nurhidaya Binte Shadan: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Hermi R Sumatoh: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Erin Soon: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Josephine Lum: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Esther Mok: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Sandra Hubert: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Peter See: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Edwin Huang Kunxiang: KK Women’s and Children’s Hospital
Yie Hou Lee: KK Research Centre, KK Women’s and Children’s Hospital
Baptiste Janela: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Mahesh Choolani: Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block
Citra Nurfarah Zaini Mattar: Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block
Yiping Fan: KK Women’s and Children’s Hospital
Tony Kiat Hon Lim: Singapore General Hospital
Dedrick Kok Hong Chan: University Surgical Cluster, National University Health System
Ker-Kan Tan: University Surgical Cluster, National University Health System
John Kit Chung Tam: Yong Loo Lin School of Medicine, National University of Singapore
Christopher Schuster: DIAID, Medical University of Vienna
Adelheid Elbe-Bürger: DIAID, Medical University of Vienna
Xiao-nong Wang: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH
Venetia Bigley: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH
Matthew Collin: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH
Muzlifah Haniffa: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH
Andreas Schlitzer: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Michael Poidinger: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Salvatore Albani: Singhealth Translational Immunology and Inflammation Centre (STIIC), 20 College Road, the Academia, Level 8 Discovery Tower
Anis Larbi: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Evan W Newell: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Jerry Kok Yen Chan: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
Florent Ginhoux: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building

Nature, 2017, vol. 546, issue 7660, 662-666

Abstract: Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.

Date: 2017
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DOI: 10.1038/nature22795

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