T cells from patients with Parkinson’s disease recognize α-synuclein peptides

David Sulzer (), Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn and Alessandro Sette ()
Additional contact information
David Sulzer: Columbia University, New York State Psychiatric Institute
Roy N. Alcalay: Columbia University
Francesca Garretti: Columbia University, New York State Psychiatric Institute
Lucien Cote: Columbia University
Ellen Kanter: Columbia University, New York State Psychiatric Institute
Julian Agin-Liebes: Columbia University, New York State Psychiatric Institute
Christopher Liong: Columbia University
Curtis McMurtrey: University of Oklahoma
William H. Hildebrand: University of Oklahoma
Xiaobo Mao: Neuroregeneration and Stem Cell Program, Johns Hopkins University School of Medicine
Valina L. Dawson: Neuroregeneration and Stem Cell Program, Johns Hopkins University School of Medicine
Ted M. Dawson: Neuroregeneration and Stem Cell Program, Johns Hopkins University School of Medicine
Carla Oseroff: La Jolla Institute for Allergy and Immunology
John Pham: La Jolla Institute for Allergy and Immunology
John Sidney: La Jolla Institute for Allergy and Immunology
Myles B. Dillon: La Jolla Institute for Allergy and Immunology
Chelsea Carpenter: La Jolla Institute for Allergy and Immunology
Daniela Weiskopf: La Jolla Institute for Allergy and Immunology
Elizabeth Phillips: Columbia University, New York State Psychiatric Institute
Simon Mallal: Columbia University, New York State Psychiatric Institute
Bjoern Peters: La Jolla Institute for Allergy and Immunology
April Frazier: La Jolla Institute for Allergy and Immunology
Cecilia S. Lindestam Arlehamn: La Jolla Institute for Allergy and Immunology
Alessandro Sette: La Jolla Institute for Allergy and Immunology

Nature, 2017, vol. 546, issue 7660, 656-661

Abstract: Epitopes derived from two regions of α-synuclein elicit immune responses in patients with Parkinson’s disease, involving IL-5-secreting CD4+ T cells, as well as IFNγ-secreting CD8+ cytotoxic T cells.

Date: 2017
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DOI: 10.1038/nature22815

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