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ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

Rohit Bose, Wouter R. Karthaus, Joshua Armenia, Wassim Abida, Phillip J. Iaquinta, Zeda Zhang, John Wongvipat, Elizabeth V. Wasmuth, Neel Shah, Patrick S. Sullivan, Michael G. Doran, Ping Wang, Anna Patruno, Yilin Zhao, Deyou Zheng, Nikolaus Schultz and Charles L. Sawyers ()
Additional contact information
Rohit Bose: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Wouter R. Karthaus: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Joshua Armenia: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Wassim Abida: Memorial Sloan Kettering Cancer Center
Phillip J. Iaquinta: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Zeda Zhang: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
John Wongvipat: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Elizabeth V. Wasmuth: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Neel Shah: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Patrick S. Sullivan: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Michael G. Doran: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Ping Wang: Albert Einstein College of Medicine
Anna Patruno: Memorial Sloan Kettering Cancer Center
Yilin Zhao: Albert Einstein College of Medicine
Deyou Zheng: Albert Einstein College of Medicine
Nikolaus Schultz: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Charles L. Sawyers: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center

Nature, 2017, vol. 546, issue 7660, 671-675

Abstract: In prostate cancer, the oncogenicity of transcription factor ERG is mediated, in part, by competition with another member of the ETS family, ERF.

Date: 2017
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DOI: 10.1038/nature22820

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