Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

Shu Zhu, Siyuan Ding, Penghua Wang, Zheng Wei, Wen Pan, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Yujiao Zhao, Kellie A. Jurado, Ningguo Feng, Liang Shan, Yuval Kluger, Jun Lu, Clara Abraham, Erol Fikrig, Harry B. Greenberg and Richard A. Flavell ()
Additional contact information
Shu Zhu: Yale University School of Medicine
Siyuan Ding: Stanford University School of Medicine
Penghua Wang: New York Medical College
Zheng Wei: Yale University School of Medicine
Wen Pan: Yale University School of Medicine
Noah W. Palm: Yale University School of Medicine
Yi Yang: Yale University School of Medicine
Hua Yu: Yale University School of Medicine
Hua-Bing Li: Yale University School of Medicine
Geng Wang: Yale University School of Medicine
Xuqiu Lei: Yale University School of Medicine
Marcel R. de Zoete: Yale University School of Medicine
Jun Zhao: Yale University School of Medicine
Yunjiang Zheng: Yale University School of Medicine
Haiwei Chen: Yale University School of Medicine
Yujiao Zhao: New York Medical College
Kellie A. Jurado: Yale University School of Medicine
Ningguo Feng: Stanford University School of Medicine
Liang Shan: Yale University School of Medicine
Yuval Kluger: Yale University School of Medicine
Jun Lu: Yale University School of Medicine
Clara Abraham: Yale University School of Medicine
Erol Fikrig: Yale University School of Medicine
Harry B. Greenberg: Stanford University School of Medicine
Richard A. Flavell: Yale University School of Medicine

Nature, 2017, vol. 546, issue 7660, 667-670

Abstract: The inflammasome receptor Nlrp9b defends against enteric viruses by interacting with double-stranded viral RNA-bound helicase Dhx9, triggering gasdermin-D-dependent pyroptotic cell death of infected cells and secretion of Il-18.

Date: 2017
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DOI: 10.1038/nature22967

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