Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

David Olmeda, Daniela Cerezo-Wallis, Erica Riveiro-Falkenbach, Paula C. Pennacchi, Marta Contreras-Alcalde, Nuria Ibarz, Metehan Cifdaloz, Xavier Catena, Tonantzin G. Calvo, Estela Cañón, Direna Alonso-Curbelo, Javier Suarez, Lisa Osterloh, Osvaldo Graña, Francisca Mulero, Diego Megías, Marta Cañamero, Jorge L. Martínez-Torrecuadrada, Chandrani Mondal, Julie Di Martino, David Lora, Inés Martinez-Corral, J. Javier Bravo-Cordero, Javier Muñoz, Susana Puig, Pablo Ortiz-Romero, José L. Rodriguez-Peralto, Sagrario Ortega and María S. Soengas ()
Additional contact information
David Olmeda: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Daniela Cerezo-Wallis: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Erica Riveiro-Falkenbach: Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre
Paula C. Pennacchi: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Marta Contreras-Alcalde: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Nuria Ibarz: Proteomics Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
Metehan Cifdaloz: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Xavier Catena: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Tonantzin G. Calvo: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Estela Cañón: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Direna Alonso-Curbelo: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Javier Suarez: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Lisa Osterloh: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Osvaldo Graña: Bioinformatics Unit, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO)
Francisca Mulero: Molecular Imaging Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
Diego Megías: Confocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
Marta Cañamero: Histopathology Unit, Biotechnology Programme,Spanish National Cancer Research Centre (CNIO)
Jorge L. Martínez-Torrecuadrada: Crystallography and Protein Engineering Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
Chandrani Mondal: The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Julie Di Martino: The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
David Lora: CIBERESP, Instituto i+12, Hospital Universitario 12 de Octubre
Inés Martinez-Corral: Transgenic Mice Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
J. Javier Bravo-Cordero: The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Javier Muñoz: Proteomics Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
Susana Puig: Melanoma Unit, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques d’August Pi i Sunyer
Pablo Ortiz-Romero: Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre
José L. Rodriguez-Peralto: Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre
Sagrario Ortega: Transgenic Mice Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
María S. Soengas: Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)

Nature, 2017, vol. 546, issue 7660, 676-680

Abstract: Genetically engineered ‘lymphoreporter’ mouse strains are used to track melanoma dissemination in vivo, identifying midkine as a tumour-secreted factor that acts at a distance, preparing pre-metastatic niches and serving as an indicator of poor prognosis in patients.

Date: 2017
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DOI: 10.1038/nature22977

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