Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells

Jiho Choi, Aaron J. Huebner, Kendell Clement, Ryan M. Walsh, Andrej Savol, Kaixuan Lin, Hongcang Gu, Bruno Di Stefano, Justin Brumbaugh, Sang-Yong Kim, Jafar Sharif, Christopher M. Rose, Arman Mohammad, Junko Odajima, Jean Charron, Toshi Shioda, Andreas Gnirke, Steven Gygi, Haruhiko Koseki, Ruslan I. Sadreyev, Andrew Xiao, Alexander Meissner and Konrad Hochedlinger ()
Additional contact information
Jiho Choi: Massachusetts General Hospital Department of Molecular Biology
Aaron J. Huebner: Massachusetts General Hospital Department of Molecular Biology
Kendell Clement: Harvard University
Ryan M. Walsh: Massachusetts General Hospital Department of Molecular Biology
Andrej Savol: Massachusetts General Hospital Department of Molecular Biology
Kaixuan Lin: Yale University School of Medicine
Hongcang Gu: Broad Institute of MIT and Harvard
Bruno Di Stefano: Massachusetts General Hospital Department of Molecular Biology
Justin Brumbaugh: Massachusetts General Hospital Department of Molecular Biology
Sang-Yong Kim: New York University Langone Medical Center
Jafar Sharif: Center for Integrative Medical Sciences, RIKEN National Research and Development Agency, 1-7-22 Suehiuro-cho, Tsurumi-ku
Christopher M. Rose: Harvard Medical School
Arman Mohammad: Broad Institute of MIT and Harvard
Junko Odajima: Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine
Jean Charron: Centre de recherche sur le cancer de l’Université Laval, CRCHU de Québec, L’Hôtel-Dieu de Québec, 9, rue McMahon
Toshi Shioda: Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine
Andreas Gnirke: Broad Institute of MIT and Harvard
Steven Gygi: Harvard Medical School
Haruhiko Koseki: Center for Integrative Medical Sciences, RIKEN National Research and Development Agency, 1-7-22 Suehiuro-cho, Tsurumi-ku
Ruslan I. Sadreyev: Massachusetts General Hospital Department of Molecular Biology
Andrew Xiao: Yale University School of Medicine
Alexander Meissner: Harvard University
Konrad Hochedlinger: Massachusetts General Hospital Department of Molecular Biology

Nature, 2017, vol. 548, issue 7666, 219-223

Abstract: Long-term culture of male embryonic stem cells in naive conditions containing Mek1/2 and Gsk3a/b inhibitors leads to irreversible changes in epigenetic and genomic stability that compromise their in vivo developmental potential.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature23274 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:548:y:2017:i:7666:d:10.1038_nature23274

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature23274

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().