Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation

Masaki Yagi, Satoshi Kishigami, Akito Tanaka, Katsunori Semi, Eiji Mizutani, Sayaka Wakayama, Teruhiko Wakayama, Takuya Yamamoto () and Yasuhiro Yamada ()
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Masaki Yagi: Center for iPS Cell Research and Application (CiRA), Kyoto University
Satoshi Kishigami: Faculty of Life and Environmental Sciences, University of Yamanashi
Akito Tanaka: Center for iPS Cell Research and Application (CiRA), Kyoto University
Katsunori Semi: Center for iPS Cell Research and Application (CiRA), Kyoto University
Eiji Mizutani: Faculty of Life and Environmental Sciences, University of Yamanashi
Sayaka Wakayama: Faculty of Life and Environmental Sciences, University of Yamanashi
Teruhiko Wakayama: Faculty of Life and Environmental Sciences, University of Yamanashi
Takuya Yamamoto: Center for iPS Cell Research and Application (CiRA), Kyoto University
Yasuhiro Yamada: Center for iPS Cell Research and Application (CiRA), Kyoto University

Nature, 2017, vol. 548, issue 7666, 224-227

Abstract: Derivation of female mouse embryonic stem cells under certain conditions induces a loss of DNA methylation and erasure of genomic imprints, which are not recovered and that may contribute to observed impaired development.

Date: 2017
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DOI: 10.1038/nature23286

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