Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Tao Xu, Kelly M. Stewart, Xiaohu Wang, Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni, Saiyong Zhu, Nan Cao, Dongwei Zhu, Yu Zhang, Katerina Akassoglou, Chen Dong (), Edward M. Driggers () and Sheng Ding ()
Additional contact information
Tao Xu: The J. David Gladstone Institutes
Kelly M. Stewart: Agios Pharmaceuticals
Xiaohu Wang: Institute for Immunology and School of Medicine, Tsinghua University
Kai Liu: The J. David Gladstone Institutes
Min Xie: The J. David Gladstone Institutes
Jae Kyu Ryu: The J. David Gladstone Institutes
Ke Li: The J. David Gladstone Institutes
Tianhua Ma: The J. David Gladstone Institutes
Haixia Wang: The J. David Gladstone Institutes
Lu Ni: Institute for Immunology and School of Medicine, Tsinghua University
Saiyong Zhu: The J. David Gladstone Institutes
Nan Cao: The J. David Gladstone Institutes
Dongwei Zhu: Agios Pharmaceuticals
Yu Zhang: The J. David Gladstone Institutes
Katerina Akassoglou: The J. David Gladstone Institutes
Chen Dong: Institute for Immunology and School of Medicine, Tsinghua University
Edward M. Driggers: Agios Pharmaceuticals
Sheng Ding: The J. David Gladstone Institutes

Nature, 2017, vol. 548, issue 7666, 228-233

Abstract: Metabolic changes in T cells can affect the genomic methylation status of key transcription factors and regulate the fate decision between induced regulatory T cells and T helper 17 cells.

Date: 2017
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DOI: 10.1038/nature23475

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