mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

Marcos Morgan, Christian Much, Monica DiGiacomo, Chiara Azzi, Ivayla Ivanova, Dimitrios M. Vitsios, Jelena Pistolic, Paul Collier, Pedro N. Moreira, Vladimir Benes, Anton J. Enright and Dónal O’Carroll ()
Additional contact information
Marcos Morgan: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
Christian Much: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
Monica DiGiacomo: European Molecular Biology Laboratory (EMBL), Mouse Biology Unit
Chiara Azzi: European Molecular Biology Laboratory (EMBL), Mouse Biology Unit
Ivayla Ivanova: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
Dimitrios M. Vitsios: European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Wellcome Genome Campus
Jelena Pistolic: European Molecular Biology Laboratory (EMBL), Genomics Core Facility
Paul Collier: European Molecular Biology Laboratory (EMBL), Genomics Core Facility
Pedro N. Moreira: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
Vladimir Benes: European Molecular Biology Laboratory (EMBL), Genomics Core Facility
Anton J. Enright: European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Wellcome Genome Campus
Dónal O’Carroll: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh

Nature, 2017, vol. 548, issue 7667, 347-351

Abstract: TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile.

Date: 2017
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DOI: 10.1038/nature23318

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