Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6

Reiya Taniguchi, Asuka Inoue, Misa Sayama, Akiharu Uwamizu, Keitaro Yamashita, Kunio Hirata, Masahito Yoshida, Yoshiki Tanaka, Hideaki E. Kato, Yoshiko Nakada-Nakura, Yuko Otani, Tomohiro Nishizawa, Takayuki Doi, Tomohiko Ohwada, Ryuichiro Ishitani, Junken Aoki () and Osamu Nureki ()
Additional contact information
Reiya Taniguchi: Graduate School of Science, The University of Tokyo
Asuka Inoue: Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
Misa Sayama: Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Akiharu Uwamizu: Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
Keitaro Yamashita: RIKEN SPring-8 Center
Kunio Hirata: Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO)
Masahito Yoshida: Laboratory of Heterocyclic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
Yoshiki Tanaka: Graduate School of Biological Sciences, Nara Institute of Science and Technology
Hideaki E. Kato: Graduate School of Science, The University of Tokyo
Yoshiko Nakada-Nakura: Graduate School of Medicine, Kyoto University
Yuko Otani: Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Tomohiro Nishizawa: Graduate School of Science, The University of Tokyo
Takayuki Doi: Laboratory of Heterocyclic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
Tomohiko Ohwada: Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Ryuichiro Ishitani: Graduate School of Science, The University of Tokyo
Junken Aoki: Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
Osamu Nureki: Graduate School of Science, The University of Tokyo

Nature, 2017, vol. 548, issue 7667, 356-360

Abstract: Determination of the crystal structure of the zebrafish LPA6 receptor shows that the lipid ligand binds to an unusual ligand-binding pocket in the receptor that is laterally accessible through the membrane.

Date: 2017
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DOI: 10.1038/nature23448

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