m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

Hua-Bing Li (), Jiyu Tong, Shu Zhu, Pedro J. Batista, Erin E. Duffy, Jun Zhao, Will Bailis, Guangchao Cao, Lina Kroehling, Yuanyuan Chen, Geng Wang, James P. Broughton, Y. Grace Chen, Yuval Kluger, Matthew D. Simon, Howard Y. Chang, Zhinan Yin () and Richard A. Flavell ()
Additional contact information
Hua-Bing Li: Yale University School of Medicine
Jiyu Tong: Yale University School of Medicine
Shu Zhu: Yale University School of Medicine
Pedro J. Batista: Center for Dynamic Regulomes, Stanford University
Erin E. Duffy: Yale University
Jun Zhao: Yale University School of Medicine
Will Bailis: Yale University School of Medicine
Guangchao Cao: Yale University School of Medicine
Lina Kroehling: Yale University School of Medicine
Yuanyuan Chen: Yale University School of Medicine
Geng Wang: Yale University School of Medicine
James P. Broughton: Center for Dynamic Regulomes, Stanford University
Y. Grace Chen: Center for Dynamic Regulomes, Stanford University
Yuval Kluger: Yale University School of Medicine
Matthew D. Simon: Yale University
Howard Y. Chang: Center for Dynamic Regulomes, Stanford University
Zhinan Yin: The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University
Richard A. Flavell: Yale University School of Medicine

Nature, 2017, vol. 548, issue 7667, 338-342

Abstract: The authors assess the role of N6-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.

Date: 2017
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DOI: 10.1038/nature23450

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