Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Julia Joung, Jesse M. Engreitz, Silvana Konermann, Omar O. Abudayyeh, Vanessa K. Verdine, Francois Aguet, Jonathan S. Gootenberg, Neville E. Sanjana, Jason B. Wright, Charles P. Fulco, Yuen-Yi Tseng, Charles H. Yoon, Jesse S. Boehm, Eric S. Lander () and Feng Zhang ()
Additional contact information
Julia Joung: MIT
Jesse M. Engreitz: Broad Institute of MIT and Harvard
Silvana Konermann: Broad Institute of MIT and Harvard
Omar O. Abudayyeh: Broad Institute of MIT and Harvard
Vanessa K. Verdine: Broad Institute of MIT and Harvard
Francois Aguet: Broad Institute of MIT and Harvard
Jonathan S. Gootenberg: Broad Institute of MIT and Harvard
Neville E. Sanjana: Broad Institute of MIT and Harvard
Jason B. Wright: Broad Institute of MIT and Harvard
Charles P. Fulco: Broad Institute of MIT and Harvard
Yuen-Yi Tseng: Broad Institute of MIT and Harvard
Charles H. Yoon: Brigham and Women’s Hospital
Jesse S. Boehm: Broad Institute of MIT and Harvard
Eric S. Lander: Broad Institute of MIT and Harvard
Feng Zhang: MIT

Nature, 2017, vol. 548, issue 7667, 343-346

Abstract: Long noncoding RNAs are investigated using a CRISPR–Cas9 activation screen and shown to confer BRAF inhibitor resistance on melanoma cells through various local mechanisms.

Date: 2017
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DOI: 10.1038/nature23451

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