cGAS surveillance of micronuclei links genome instability to innate immunity

Karen J. Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel J. Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline K. Rainger, Andrea Leitch, Ruby T. Osborn, Ann P. Wheeler, Marcin Nowotny, Nick Gilbert, Tamir Chandra, Martin A. M. Reijns () and Andrew P. Jackson ()
Additional contact information
Karen J. Mackenzie: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Paula Carroll: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Carol-Anne Martin: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Olga Murina: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Adeline Fluteau: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Daniel J. Simpson: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Nelly Olova: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Hannah Sutcliffe: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Jacqueline K. Rainger: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Andrea Leitch: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Ruby T. Osborn: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Ann P. Wheeler: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Marcin Nowotny: Laboratory of Protein Structure, International Institute of Molecular and Cell Biology
Nick Gilbert: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Tamir Chandra: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Martin A. M. Reijns: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh
Andrew P. Jackson: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh

Nature, 2017, vol. 548, issue 7668, 461-465

Abstract: The cytoplasmic DNA sensor cGAS detects DNA in ruptured micronuclei and activates an innate immune response.

Date: 2017
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DOI: 10.1038/nature23449

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