Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity

Cody J. Wenthur, Bin Zhou and Kim D. Janda ()
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Cody J. Wenthur: The Skaggs Institute for Chemical Biology, The Scripps Research Institute
Bin Zhou: The Skaggs Institute for Chemical Biology, The Scripps Research Institute
Kim D. Janda: The Skaggs Institute for Chemical Biology, The Scripps Research Institute

Nature, 2017, vol. 548, issue 7668, 476-479

Abstract: A vaccine-driven approach shows that the prominent stimulant features of the psychoactive profile of fenethylline can be attributed to amphetamine, with synergistic support from theophylline, and no direct contributions from the parent drug molecule.

Date: 2017
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DOI: 10.1038/nature23464

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