CDK4/6 inhibition triggers anti-tumour immunity

Shom Goel (), Molly J. DeCristo, April C. Watt, Haley BrinJones, Jaclyn Sceneay, Ben B. Li, Naveed Khan, Jessalyn M. Ubellacker, Shaozhen Xie, Otto Metzger-Filho, Jeremy Hoog, Matthew J. Ellis, Cynthia X. Ma, Susanne Ramm, Ian E. Krop, Eric P. Winer, Thomas M. Roberts, Hye-Jung Kim, Sandra S. McAllister () and Jean J. Zhao ()
Additional contact information
Shom Goel: Dana-Farber Cancer Institute
Molly J. DeCristo: Harvard Medical School
April C. Watt: Dana-Farber Cancer Institute
Haley BrinJones: Dana-Farber Cancer Institute
Jaclyn Sceneay: Harvard Medical School
Ben B. Li: Dana-Farber Cancer Institute
Naveed Khan: Dana-Farber Cancer Institute
Jessalyn M. Ubellacker: Harvard Medical School
Shaozhen Xie: Dana-Farber Cancer Institute
Otto Metzger-Filho: Dana-Farber Cancer Institute
Jeremy Hoog: Washington University School of Medicine
Matthew J. Ellis: Lester and Sue Smith Breast Center, Baylor College of Medicine
Cynthia X. Ma: Washington University School of Medicine
Susanne Ramm: Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School
Ian E. Krop: Dana-Farber Cancer Institute
Eric P. Winer: Dana-Farber Cancer Institute
Thomas M. Roberts: Dana-Farber Cancer Institute
Hye-Jung Kim: Dana-Farber Cancer Institute
Sandra S. McAllister: Harvard Medical School
Jean J. Zhao: Dana-Farber Cancer Institute

Nature, 2017, vol. 548, issue 7668, 471-475

Abstract: Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.

Date: 2017
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DOI: 10.1038/nature23465

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