Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

Weike Pei, Thorsten B. Feyerabend, Jens Rössler, Xi Wang, Daniel Postrach, Katrin Busch, Immanuel Rode, Kay Klapproth, Nikolaus Dietlein, Claudia Quedenau, Wei Chen, Sascha Sauer, Stephan Wolf, Thomas Höfer () and Hans-Reimer Rodewald ()
Additional contact information
Weike Pei: German Cancer Research Center
Thorsten B. Feyerabend: German Cancer Research Center
Jens Rössler: German Cancer Research Center
Xi Wang: German Cancer Research Center
Daniel Postrach: German Cancer Research Center
Katrin Busch: German Cancer Research Center
Immanuel Rode: German Cancer Research Center
Kay Klapproth: German Cancer Research Center
Nikolaus Dietlein: German Cancer Research Center
Claudia Quedenau: Max Delbrück Center, Scientific Genomics Platforms (BIMSB/BIH)
Wei Chen: Max Delbrück Center, Scientific Genomics Platforms (BIMSB/BIH)
Sascha Sauer: Max Delbrück Center, Scientific Genomics Platforms (BIMSB/BIH)
Stephan Wolf: Genomics & Proteomics Core Facilities, German Cancer Research Center
Thomas Höfer: German Cancer Research Center
Hans-Reimer Rodewald: German Cancer Research Center

Nature, 2017, vol. 548, issue 7668, 456-460

Abstract: An artificial recombination locus, Polylox, that can generate hundreds of thousands of individual barcodes is used to trace the fates of haematopoietic stem cells in mice.

Date: 2017
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DOI: 10.1038/nature23653

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