Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar and Jun Takahashi ()
Additional contact information
Tetsuhiro Kikuchi: Center for iPS Cell Research and Application, Kyoto University
Asuka Morizane: Center for iPS Cell Research and Application, Kyoto University
Daisuke Doi: Center for iPS Cell Research and Application, Kyoto University
Hiroaki Magotani: Center for iPS Cell Research and Application, Kyoto University
Hirotaka Onoe: RIKEN Center for Life Science Technologies
Takuya Hayashi: RIKEN Center for Life Science Technologies
Hiroshi Mizuma: RIKEN Center for Life Science Technologies
Sayuki Takara: RIKEN Center for Life Science Technologies
Ryosuke Takahashi: Kyoto University Graduate School of Medicine
Haruhisa Inoue: Center for iPS Cell Research and Application, Kyoto University
Satoshi Morita: Kyoto University Graduate School of Medicine
Michio Yamamoto: Kyoto University Graduate School of Medicine
Keisuke Okita: Center for iPS Cell Research and Application, Kyoto University
Masato Nakagawa: Center for iPS Cell Research and Application, Kyoto University
Malin Parmar: Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University
Jun Takahashi: Center for iPS Cell Research and Application, Kyoto University

Nature, 2017, vol. 548, issue 7669, 592-596

Abstract: In a preclinical study, dopaminergic neurons derived from human induced pluripotent stem cells were implanted into a primate model of Parkinson’s disease, where they were found to exhibit long-term survival, function as mid-brain dopaminergic neurons, and increase spontaneous movements.

Date: 2017
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DOI: 10.1038/nature23664

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