Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

Kai Yang, Daniel Bastardo Blanco, Geoffrey Neale, Peter Vogel, Julian Avila, Clary B. Clish, Chuan Wu, Sharad Shrestha, Sherri Rankin, Lingyun Long, Anil Kc and Hongbo Chi ()
Additional contact information
Kai Yang: St Jude Children’s Research Hospital
Daniel Bastardo Blanco: St Jude Children’s Research Hospital
Geoffrey Neale: Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital
Peter Vogel: St Jude Children’s Research Hospital
Julian Avila: Metabolomics Platform, Broad Institute of MIT and Harvard University
Clary B. Clish: Metabolomics Platform, Broad Institute of MIT and Harvard University
Chuan Wu: Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Sharad Shrestha: St Jude Children’s Research Hospital
Sherri Rankin: St Jude Children’s Research Hospital
Lingyun Long: St Jude Children’s Research Hospital
Anil Kc: St Jude Children’s Research Hospital
Hongbo Chi: St Jude Children’s Research Hospital

Nature, 2017, vol. 548, issue 7669, 602-606

Abstract: The tumour suppressor liver kinase B1 (LKB1) regulates the metabolic and functional fitness of regulatory T cells in the control of immune tolerance and homeostasis.

Date: 2017
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DOI: 10.1038/nature23665

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