Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

Kathrin Pieper, Joshua Tan, Luca Piccoli, Mathilde Foglierini, Sonia Barbieri, Yiwei Chen, Chiara Silacci-Fregni, Tobias Wolf, David Jarrossay, Marica Anderle, Abdirahman Abdi, Francis M. Ndungu, Ogobara K. Doumbo, Boubacar Traore, Tuan M. Tran, Said Jongo, Isabelle Zenklusen, Peter D. Crompton, Claudia Daubenberger, Peter C. Bull, Federica Sallusto and Antonio Lanzavecchia ()
Additional contact information
Kathrin Pieper: Institute for Research in Biomedicine, Università della Svizzera Italiana
Joshua Tan: Institute for Research in Biomedicine, Università della Svizzera Italiana
Luca Piccoli: Institute for Research in Biomedicine, Università della Svizzera Italiana
Mathilde Foglierini: Institute for Research in Biomedicine, Università della Svizzera Italiana
Sonia Barbieri: Institute for Research in Biomedicine, Università della Svizzera Italiana
Yiwei Chen: Institute for Research in Biomedicine, Università della Svizzera Italiana
Chiara Silacci-Fregni: Institute for Research in Biomedicine, Università della Svizzera Italiana
Tobias Wolf: Institute for Research in Biomedicine, Università della Svizzera Italiana
David Jarrossay: Institute for Research in Biomedicine, Università della Svizzera Italiana
Marica Anderle: Institute for Research in Biomedicine, Università della Svizzera Italiana
Abdirahman Abdi: KEMRI-Wellcome Trust Research Programme
Francis M. Ndungu: KEMRI-Wellcome Trust Research Programme
Ogobara K. Doumbo: Malaria Research and Training Centre, University of Sciences, Technique, and Technology of Bamako
Boubacar Traore: Malaria Research and Training Centre, University of Sciences, Technique, and Technology of Bamako
Tuan M. Tran: Indiana University School of Medicine
Said Jongo: Ifakara Health Institute, Bagamoyo Clinical Trial Unit
Isabelle Zenklusen: Swiss Tropical and Public Health Institute, Clinical Immunology Unit
Peter D. Crompton: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Claudia Daubenberger: Swiss Tropical and Public Health Institute, Clinical Immunology Unit
Peter C. Bull: University of Cambridge
Federica Sallusto: Institute for Research in Biomedicine, Università della Svizzera Italiana
Antonio Lanzavecchia: Institute for Research in Biomedicine, Università della Svizzera Italiana

Nature, 2017, vol. 548, issue 7669, 597-601

Abstract: Up to 10% of individuals in malaria-endemic regions produce antibodies that react to malaria antigens through an additional LAIR1 domain that is inserted by two different insertion modalities.

Date: 2017
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DOI: 10.1038/nature23670

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