Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Christina D. Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y. Nguyen, Allison Wing, Emily L. Goldberg, Yun-Hee Youm, Chester W. Brown, John Elsworth, Matthew S. Rodeheffer, Joachim L. Schultze and Vishwa Deep Dixit ()
Additional contact information
Christina D. Camell: Yale School of Medicine
Jil Sander: Genomics and Immunoregulation, LIMES-Institute, University of Bonn
Olga Spadaro: Yale School of Medicine
Aileen Lee: Yale School of Medicine
Kim Y. Nguyen: Yale School of Medicine
Allison Wing: Cellular and Developmental Biology, Yale School of Medicine
Emily L. Goldberg: Yale School of Medicine
Yun-Hee Youm: Yale School of Medicine
Chester W. Brown: University of Tennessee Health Science Center
John Elsworth: Yale School of Medicine
Matthew S. Rodeheffer: Yale School of Medicine
Joachim L. Schultze: Genomics and Immunoregulation, LIMES-Institute, University of Bonn
Vishwa Deep Dixit: Yale School of Medicine

Nature, 2017, vol. 550, issue 7674, 119-123

Abstract: Lipolysis declines with age because NLRP3 inflammasome-activated adipose tissue macrophages reduce levels of noradrenaline by upregulating genes that control its degradation, such as GDF3 and MAOA.

Date: 2017
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DOI: 10.1038/nature24022

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